Review





Similar Products

rag2  (Cyagen Biosciences)
94
Cyagen Biosciences rag2
Rag2, supplied by Cyagen Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rag2/Rag2/pm42854554-163-1-3
Average 94 stars, based on 1 article reviews
rag2 - by Bioz Stars, 2026-11
94/100 stars
  Buy from Supplier
female rag2 il2rg double knockout r2g2 mice  (Inotiv)
94
Inotiv female rag2 il2rg double knockout r2g2 mice
066ATZ reduces tumor growth rate in a xenograft model of NSCLC (A) The growth curves of H1975∗ xenograft tumor in <t>R2G2</t> mice. Data are presented as mean ± SEM ( n = 5). 066ATZ (100 mg/kg) or vehicle was IP injected 5 times a week after the tumors reached ∼150 mm 3 . One animal died in the treatment group on day 39 for an unknown cause when the tumor reached a size of ∼550 mm 3 . All other mice were sacrificed when the tumors reached ∼1,000 mm 3 . On day 24, the average tumor volume was significantly smaller in the treatment group ( p < 0.01). p values were calculated using Student’s t test (two-tailed unpaired t test) with Welch’s correction in GraphPad Prism 10.0 (GraphPad Software, San Diego, CA). (B) The growth curves of H1975∗ xenograft tumor in R2G2 mice after DOX-induced PIP4K2A/2B knockdown. Data are presented as mean ± SEM ( n = 5). When the tumors reached ∼150 mm 3 , DOX was administered to the mice continuously through drinking water (1 mg/mL). Tumor tissues were harvested at the end of the experiment, homogenized, and analyzed by WB (shown below the growth curves). (C) In vitro , neither 066ATZ (20 μM) nor DOX (0.2 μg/mL) affected the growth rate of cultured H1975∗ cells. Data are presented as mean ± SEM ( n = 6). The cell numbers were measured by CellTiter-Glo.
Female Rag2 Il2rg Double Knockout R2g2 Mice, supplied by Inotiv, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rag2/Rag2-Il2rg+double+knockout+mice/pmc13206749-305-1-10
Average 94 stars, based on 1 article reviews
female rag2 il2rg double knockout r2g2 mice - by Bioz Stars, 2026-11
94/100 stars
  Buy from Supplier
rag2 deficient γ chain  (Jackson Laboratory)
86
Jackson Laboratory rag2 deficient γ chain
066ATZ reduces tumor growth rate in a xenograft model of NSCLC (A) The growth curves of H1975∗ xenograft tumor in <t>R2G2</t> mice. Data are presented as mean ± SEM ( n = 5). 066ATZ (100 mg/kg) or vehicle was IP injected 5 times a week after the tumors reached ∼150 mm 3 . One animal died in the treatment group on day 39 for an unknown cause when the tumor reached a size of ∼550 mm 3 . All other mice were sacrificed when the tumors reached ∼1,000 mm 3 . On day 24, the average tumor volume was significantly smaller in the treatment group ( p < 0.01). p values were calculated using Student’s t test (two-tailed unpaired t test) with Welch’s correction in GraphPad Prism 10.0 (GraphPad Software, San Diego, CA). (B) The growth curves of H1975∗ xenograft tumor in R2G2 mice after DOX-induced PIP4K2A/2B knockdown. Data are presented as mean ± SEM ( n = 5). When the tumors reached ∼150 mm 3 , DOX was administered to the mice continuously through drinking water (1 mg/mL). Tumor tissues were harvested at the end of the experiment, homogenized, and analyzed by WB (shown below the growth curves). (C) In vitro , neither 066ATZ (20 μM) nor DOX (0.2 μg/mL) affected the growth rate of cultured H1975∗ cells. Data are presented as mean ± SEM ( n = 6). The cell numbers were measured by CellTiter-Glo.
Rag2 Deficient γ Chain, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rag2/chain+deficient+deficient+rag2+%CE%B3/pmc13199098-249-14-24
Average 86 stars, based on 1 article reviews
rag2 deficient γ chain - by Bioz Stars, 2026-11
86/100 stars
  Buy from Supplier
female recipient rag2  (Janvier Labs)
86
Janvier Labs female recipient rag2
066ATZ reduces tumor growth rate in a xenograft model of NSCLC (A) The growth curves of H1975∗ xenograft tumor in <t>R2G2</t> mice. Data are presented as mean ± SEM ( n = 5). 066ATZ (100 mg/kg) or vehicle was IP injected 5 times a week after the tumors reached ∼150 mm 3 . One animal died in the treatment group on day 39 for an unknown cause when the tumor reached a size of ∼550 mm 3 . All other mice were sacrificed when the tumors reached ∼1,000 mm 3 . On day 24, the average tumor volume was significantly smaller in the treatment group ( p < 0.01). p values were calculated using Student’s t test (two-tailed unpaired t test) with Welch’s correction in GraphPad Prism 10.0 (GraphPad Software, San Diego, CA). (B) The growth curves of H1975∗ xenograft tumor in R2G2 mice after DOX-induced PIP4K2A/2B knockdown. Data are presented as mean ± SEM ( n = 5). When the tumors reached ∼150 mm 3 , DOX was administered to the mice continuously through drinking water (1 mg/mL). Tumor tissues were harvested at the end of the experiment, homogenized, and analyzed by WB (shown below the growth curves). (C) In vitro , neither 066ATZ (20 μM) nor DOX (0.2 μg/mL) affected the growth rate of cultured H1975∗ cells. Data are presented as mean ± SEM ( n = 6). The cell numbers were measured by CellTiter-Glo.
Female Recipient Rag2, supplied by Janvier Labs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rag2/6jrj+c57bl+mice/pm42097141-250-0-25
Average 86 stars, based on 1 article reviews
female recipient rag2 - by Bioz Stars, 2026-11
86/100 stars
  Buy from Supplier
sprague dawley rag2 il2rg rat models  (Dawley Inc)
86
Dawley Inc sprague dawley rag2 il2rg rat models
066ATZ reduces tumor growth rate in a xenograft model of NSCLC (A) The growth curves of H1975∗ xenograft tumor in <t>R2G2</t> mice. Data are presented as mean ± SEM ( n = 5). 066ATZ (100 mg/kg) or vehicle was IP injected 5 times a week after the tumors reached ∼150 mm 3 . One animal died in the treatment group on day 39 for an unknown cause when the tumor reached a size of ∼550 mm 3 . All other mice were sacrificed when the tumors reached ∼1,000 mm 3 . On day 24, the average tumor volume was significantly smaller in the treatment group ( p < 0.01). p values were calculated using Student’s t test (two-tailed unpaired t test) with Welch’s correction in GraphPad Prism 10.0 (GraphPad Software, San Diego, CA). (B) The growth curves of H1975∗ xenograft tumor in R2G2 mice after DOX-induced PIP4K2A/2B knockdown. Data are presented as mean ± SEM ( n = 5). When the tumors reached ∼150 mm 3 , DOX was administered to the mice continuously through drinking water (1 mg/mL). Tumor tissues were harvested at the end of the experiment, homogenized, and analyzed by WB (shown below the growth curves). (C) In vitro , neither 066ATZ (20 μM) nor DOX (0.2 μg/mL) affected the growth rate of cultured H1975∗ cells. Data are presented as mean ± SEM ( n = 6). The cell numbers were measured by CellTiter-Glo.
Sprague Dawley Rag2 Il2rg Rat Models, supplied by Dawley Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rag2/models+rat/pm42093096-144-9-10
Average 86 stars, based on 1 article reviews
sprague dawley rag2 il2rg rat models - by Bioz Stars, 2026-11
86/100 stars
  Buy from Supplier
rag2  (Jackson Laboratory)
86
Jackson Laboratory rag2
066ATZ reduces tumor growth rate in a xenograft model of NSCLC (A) The growth curves of H1975∗ xenograft tumor in <t>R2G2</t> mice. Data are presented as mean ± SEM ( n = 5). 066ATZ (100 mg/kg) or vehicle was IP injected 5 times a week after the tumors reached ∼150 mm 3 . One animal died in the treatment group on day 39 for an unknown cause when the tumor reached a size of ∼550 mm 3 . All other mice were sacrificed when the tumors reached ∼1,000 mm 3 . On day 24, the average tumor volume was significantly smaller in the treatment group ( p < 0.01). p values were calculated using Student’s t test (two-tailed unpaired t test) with Welch’s correction in GraphPad Prism 10.0 (GraphPad Software, San Diego, CA). (B) The growth curves of H1975∗ xenograft tumor in R2G2 mice after DOX-induced PIP4K2A/2B knockdown. Data are presented as mean ± SEM ( n = 5). When the tumors reached ∼150 mm 3 , DOX was administered to the mice continuously through drinking water (1 mg/mL). Tumor tissues were harvested at the end of the experiment, homogenized, and analyzed by WB (shown below the growth curves). (C) In vitro , neither 066ATZ (20 μM) nor DOX (0.2 μg/mL) affected the growth rate of cultured H1975∗ cells. Data are presented as mean ± SEM ( n = 6). The cell numbers were measured by CellTiter-Glo.
Rag2, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rag2/rag2/pm42056521-487-6-13
Average 86 stars, based on 1 article reviews
rag2 - by Bioz Stars, 2026-11
86/100 stars
  Buy from Supplier
il2rg  (Inotiv)
94
Inotiv il2rg
066ATZ reduces tumor growth rate in a xenograft model of NSCLC (A) The growth curves of H1975∗ xenograft tumor in <t>R2G2</t> mice. Data are presented as mean ± SEM ( n = 5). 066ATZ (100 mg/kg) or vehicle was IP injected 5 times a week after the tumors reached ∼150 mm 3 . One animal died in the treatment group on day 39 for an unknown cause when the tumor reached a size of ∼550 mm 3 . All other mice were sacrificed when the tumors reached ∼1,000 mm 3 . On day 24, the average tumor volume was significantly smaller in the treatment group ( p < 0.01). p values were calculated using Student’s t test (two-tailed unpaired t test) with Welch’s correction in GraphPad Prism 10.0 (GraphPad Software, San Diego, CA). (B) The growth curves of H1975∗ xenograft tumor in R2G2 mice after DOX-induced PIP4K2A/2B knockdown. Data are presented as mean ± SEM ( n = 5). When the tumors reached ∼150 mm 3 , DOX was administered to the mice continuously through drinking water (1 mg/mL). Tumor tissues were harvested at the end of the experiment, homogenized, and analyzed by WB (shown below the growth curves). (C) In vitro , neither 066ATZ (20 μM) nor DOX (0.2 μg/mL) affected the growth rate of cultured H1975∗ cells. Data are presented as mean ± SEM ( n = 6). The cell numbers were measured by CellTiter-Glo.
Il2rg, supplied by Inotiv, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rag2/Rag2-Il2rg+double+knockout+mice/pmc13173943-430-30-41
Average 94 stars, based on 1 article reviews
il2rg - by Bioz Stars, 2026-11
94/100 stars
  Buy from Supplier
common γchain  (Taconic Biosciences)
97
Taconic Biosciences common γchain
066ATZ reduces tumor growth rate in a xenograft model of NSCLC (A) The growth curves of H1975∗ xenograft tumor in <t>R2G2</t> mice. Data are presented as mean ± SEM ( n = 5). 066ATZ (100 mg/kg) or vehicle was IP injected 5 times a week after the tumors reached ∼150 mm 3 . One animal died in the treatment group on day 39 for an unknown cause when the tumor reached a size of ∼550 mm 3 . All other mice were sacrificed when the tumors reached ∼1,000 mm 3 . On day 24, the average tumor volume was significantly smaller in the treatment group ( p < 0.01). p values were calculated using Student’s t test (two-tailed unpaired t test) with Welch’s correction in GraphPad Prism 10.0 (GraphPad Software, San Diego, CA). (B) The growth curves of H1975∗ xenograft tumor in R2G2 mice after DOX-induced PIP4K2A/2B knockdown. Data are presented as mean ± SEM ( n = 5). When the tumors reached ∼150 mm 3 , DOX was administered to the mice continuously through drinking water (1 mg/mL). Tumor tissues were harvested at the end of the experiment, homogenized, and analyzed by WB (shown below the growth curves). (C) In vitro , neither 066ATZ (20 μM) nor DOX (0.2 μg/mL) affected the growth rate of cultured H1975∗ cells. Data are presented as mean ± SEM ( n = 6). The cell numbers were measured by CellTiter-Glo.
Common γchain, supplied by Taconic Biosciences, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rag2/Rag2+-+Model+RAG2/us12595285-463-1-14
Average 97 stars, based on 1 article reviews
common γchain - by Bioz Stars, 2026-11
97/100 stars
  Buy from Supplier
rag2  (Taconic Biosciences)
97
Taconic Biosciences rag2
066ATZ reduces tumor growth rate in a xenograft model of NSCLC (A) The growth curves of H1975∗ xenograft tumor in <t>R2G2</t> mice. Data are presented as mean ± SEM ( n = 5). 066ATZ (100 mg/kg) or vehicle was IP injected 5 times a week after the tumors reached ∼150 mm 3 . One animal died in the treatment group on day 39 for an unknown cause when the tumor reached a size of ∼550 mm 3 . All other mice were sacrificed when the tumors reached ∼1,000 mm 3 . On day 24, the average tumor volume was significantly smaller in the treatment group ( p < 0.01). p values were calculated using Student’s t test (two-tailed unpaired t test) with Welch’s correction in GraphPad Prism 10.0 (GraphPad Software, San Diego, CA). (B) The growth curves of H1975∗ xenograft tumor in R2G2 mice after DOX-induced PIP4K2A/2B knockdown. Data are presented as mean ± SEM ( n = 5). When the tumors reached ∼150 mm 3 , DOX was administered to the mice continuously through drinking water (1 mg/mL). Tumor tissues were harvested at the end of the experiment, homogenized, and analyzed by WB (shown below the growth curves). (C) In vitro , neither 066ATZ (20 μM) nor DOX (0.2 μg/mL) affected the growth rate of cultured H1975∗ cells. Data are presented as mean ± SEM ( n = 6). The cell numbers were measured by CellTiter-Glo.
Rag2, supplied by Taconic Biosciences, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rag2/Rag2+-+Model+RAG2/us12595285-463-3-14
Average 97 stars, based on 1 article reviews
rag2 - by Bioz Stars, 2026-11
97/100 stars
  Buy from Supplier

Image Search Results


066ATZ reduces tumor growth rate in a xenograft model of NSCLC (A) The growth curves of H1975∗ xenograft tumor in R2G2 mice. Data are presented as mean ± SEM ( n = 5). 066ATZ (100 mg/kg) or vehicle was IP injected 5 times a week after the tumors reached ∼150 mm 3 . One animal died in the treatment group on day 39 for an unknown cause when the tumor reached a size of ∼550 mm 3 . All other mice were sacrificed when the tumors reached ∼1,000 mm 3 . On day 24, the average tumor volume was significantly smaller in the treatment group ( p < 0.01). p values were calculated using Student’s t test (two-tailed unpaired t test) with Welch’s correction in GraphPad Prism 10.0 (GraphPad Software, San Diego, CA). (B) The growth curves of H1975∗ xenograft tumor in R2G2 mice after DOX-induced PIP4K2A/2B knockdown. Data are presented as mean ± SEM ( n = 5). When the tumors reached ∼150 mm 3 , DOX was administered to the mice continuously through drinking water (1 mg/mL). Tumor tissues were harvested at the end of the experiment, homogenized, and analyzed by WB (shown below the growth curves). (C) In vitro , neither 066ATZ (20 μM) nor DOX (0.2 μg/mL) affected the growth rate of cultured H1975∗ cells. Data are presented as mean ± SEM ( n = 6). The cell numbers were measured by CellTiter-Glo.

Journal: iScience

Article Title: PIP4K2A/2B inhibitor suppresses tumor growth in a xenograft model of NSCLC

doi: 10.1016/j.isci.2026.115952

Figure Lengend Snippet: 066ATZ reduces tumor growth rate in a xenograft model of NSCLC (A) The growth curves of H1975∗ xenograft tumor in R2G2 mice. Data are presented as mean ± SEM ( n = 5). 066ATZ (100 mg/kg) or vehicle was IP injected 5 times a week after the tumors reached ∼150 mm 3 . One animal died in the treatment group on day 39 for an unknown cause when the tumor reached a size of ∼550 mm 3 . All other mice were sacrificed when the tumors reached ∼1,000 mm 3 . On day 24, the average tumor volume was significantly smaller in the treatment group ( p < 0.01). p values were calculated using Student’s t test (two-tailed unpaired t test) with Welch’s correction in GraphPad Prism 10.0 (GraphPad Software, San Diego, CA). (B) The growth curves of H1975∗ xenograft tumor in R2G2 mice after DOX-induced PIP4K2A/2B knockdown. Data are presented as mean ± SEM ( n = 5). When the tumors reached ∼150 mm 3 , DOX was administered to the mice continuously through drinking water (1 mg/mL). Tumor tissues were harvested at the end of the experiment, homogenized, and analyzed by WB (shown below the growth curves). (C) In vitro , neither 066ATZ (20 μM) nor DOX (0.2 μg/mL) affected the growth rate of cultured H1975∗ cells. Data are presented as mean ± SEM ( n = 6). The cell numbers were measured by CellTiter-Glo.

Article Snippet: Seven-week-old female Rag2/IL2RG double knockout (R2G2) mice were purchased from Envigo and housed under a 12-h light/12-h dark cycle in a temperature- and humidity-controlled facility maintained by the Yale Animal Resources Center (YARC), with ad libitum access to food and water.

Techniques: Injection, Two Tailed Test, Software, Knockdown, In Vitro, Cell Culture